Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins
نویسندگان
چکیده
منابع مشابه
Organization of HIV-1 capsid proteins on a lipid monolayer.
In an in vitro system that mimics the assembly of immature human immunodeficiency virus (HIV) particles, ordered arrays of HIV-1 capsid (CA) proteins encoded by the viral gag gene have been obtained by incubation of histidine-tagged capsid proteins (His-HIVCA) beneath lipid monolayers containing the nickel-chelating lipid, 1,2-di-O-hexadecyl-sn-glycero-3-(1'-2"-R-hydroxy-3'-N-(5-amino-1- carbox...
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It is known that the retrovirus capsids possess a fullerene-like structure. These caged polyhedral arrangements are built entirely fromhexagons and exactly 12 pentagons according to the Euler theorem. Viral capsids are composed of capsid proteins, which create the hexagon and pentagon shapes by groups of six (hexamer) and five (pentamer) proteins. Different distributions of these 12 pentamers r...
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The identification of novel antiretroviral agents is required to provide alternative treatment options for HIV-1-infected patients. The screening of a phenotypic cell-based viral replication assay led to the identification of a novel class of 4,5-dihydro-1H-pyrrolo[3,4-c]pyrazol-6-one (pyrrolopyrazolone) HIV-1 inhibitors, exemplified by two compounds: BI-1 and BI-2. These compounds inhibited ea...
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Timely disassembly of viral core composed of self-assembled capsid (CA) in infected host cells is crucial for retroviral replication. Extensive in vitro studies to date on the self-assembly/disassembly mechanism of human immunodeficiency virus type 1 (HIV-1) CA have revealed its core structure and amino acid residues essential for CA-CA intermolecular interaction. However, little is known about...
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Negative Factor, Nef Yes, cleaved by PR CD4/MHC downregulation; T-cell activation; moderate enhancer of viral infectivity; blocks apoptosis; pathogenicity determinant CD4, CD28, MHC-I, MHC-II, TCR-CD3ζ, other cell-surface proteins Nef connects immunologically important host surface proteins to clathrin-dependent and -independent sorting pathways to regulate traffi cking, degradation, and immune...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2021
ISSN: 2218-273X
DOI: 10.3390/biom11020208